NIR-II-activated biocompatible hollow nanocarbons for cancer photothermal therapy

NIR-II-activated biocompatible hollow nanocarbons for cancer photothermal therapy

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Abstract Photothermal therapy has attracted extensive attentions in cancer treatment due to its precise spatial-temporal controllability, minimal invasiveness, and negligible side sofia barclay sexy effects.However, two major deficiencies, unsatisfactory heat conversion efficiency and limited tissue penetration depth, hugely impeded its clinical application.In this work, hollow carbon nanosphere modified with polyethylene glycol-graft-polyethylenimine (HPP) was elaborately synthesized.The synthesized HPP owns outstanding physical properties as a virginia mill works tobacco road acacia photothermal agent, such as uniform core-shell structure, good biocompatibility and excellent heat conversion efficiency.Upon NIR-II laser irradiation, the intracellular HPP shows excellent photothermal activity towards cancer cell killing.

In addition, depending on the large internal cavity of HPP, the extended biomedical application as drug copyright was also demonstrated.In general, the synthesized HPP holds a great potential in NIR-II laser-activated cancer photothermal therapy.